Distinct MLL gene rearrangements associated with successive acute monocytic and lymphoblastic leukemias in the same patient

P Jonveaux; J Hillion; O Bernard; M Le Coniat; J Derré; M Flexor; C J Larsen; R Berger

Distinct MLL gene rearrangements associated with successive acute monocytic and lymphoblastic leukemias in the same patient

Leukemia. 1994 Dec;8(12):2224-7.

Authors

P Jonveaux¹, J Hillion, O Bernard, M Le Coniat, J Derré, M Flexor, C J Larsen, R Berger

Affiliation

¹ Unité INSERM U301, Institut de Génétique Moléculaire, Paris, France.

PMID: 7808011

Abstract

A patient with acute monocytic leukemia (AMoL) and t(6;11)(q27;q23) developed acute lymphoblastic leukemia (ALL) and t(4;11)(q21;23), 10 months after complete remission of the AMoL. The MLL gene, normally located at band 11q23, appeared differently rearranged in the cells of these two leukemias, showing a different origin for the two malignant clones. The responsibility of etoposide, used in treatment of the AML, in the occurrence of the ALL is probable in this patient.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Chromosomes, Human, Pair 11*
Chromosomes, Human, Pair 4
Chromosomes, Human, Pair 6
Etoposide / adverse effects
Gene Rearrangement*
Humans
In Situ Hybridization, Fluorescence
Leukemia, Monocytic, Acute / drug therapy
Leukemia, Monocytic, Acute / genetics*
Male
Precursor Cell Lymphoblastic Leukemia-Lymphoma / chemically induced
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
Translocation, Genetic

Substances

Etoposide