Direct and inverted reciprocal chromosome insertions between chromosomes 7 and 14 in a woman with recurrent miscarriages

Y T Wang; S Bajalica; F Y Han; Z C Wang; T H Bui; Y G Xie

doi:10.1002/ajmg.1320520319

Direct and inverted reciprocal chromosome insertions between chromosomes 7 and 14 in a woman with recurrent miscarriages

Am J Med Genet. 1994 Sep 1;52(3):349-51. doi: 10.1002/ajmg.1320520319.

Authors

Y T Wang¹, S Bajalica, F Y Han, Z C Wang, T H Bui, Y G Xie

Affiliation

¹ Institute of Medical Genetics, Henan Province Hospital, Zheng Zhou, P. R. China.

PMID: 7810568
DOI: 10.1002/ajmg.1320520319

Abstract

We present the first case of direct and inverted reciprocal chromosome insertions between human chromosomes 7 and 14, ascertained because of repeated spontaneous abortions. Prometaphase GTG banding analysis showed the karyotype to be 46, XX, inv ins (7;14)(7pter-->7q11.23::14q32.2-->14q 22::7q21.2-->7qter), dir ins(14;7)(14pter-->14q 22::7q11.23-->7q21.2::14q32.2-->14qter). Origins of the insertion have been confirmed by chromosome painting with libraries specific for chromosomes 7 and 14 using fluorescence in situ hybridization.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Abortion, Habitual / genetics*
Adult
Chromosome Aberrations*
Chromosome Banding
Chromosomes, Human, Pair 14* / ultrastructure
Chromosomes, Human, Pair 7* / ultrastructure
Female
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Pregnancy