Abstract
Plasma PCR for human cytomegalovirus (CMV) DNA was compared with bronchoalveolar lavage (BAL) fluid culture as an indicator for disseminated CMV infection. Thirteen (32.5%) of 40 consecutive bone marrow transplant (BMT) recipients were BAL fluid culture positive for CMV on day 35 post-BMT, and 9 (69%) of the 13 had positive plasma PCRs between days 28 and 49. Of the 27 with negative BAL fluid cultures, 2 (7%) had positive plasma PCRs (P < 0.001). Plasma CMV DNA in BMT recipients is a useful clinical marker for serious infection.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Base Sequence
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Bone Marrow Transplantation*
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Bronchoalveolar Lavage Fluid*
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Cell Line
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Cytomegalovirus / genetics
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Cytomegalovirus / growth & development
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Cytomegalovirus / isolation & purification*
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Cytomegalovirus Infections / microbiology*
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Cytomegalovirus Infections / prevention & control
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DNA, Viral / blood
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DNA, Viral / isolation & purification*
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Ganciclovir / therapeutic use
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Humans
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Immunocompromised Host
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Lung Diseases, Interstitial / microbiology*
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Lung Diseases, Interstitial / prevention & control
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Molecular Sequence Data
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Pneumonia, Viral / microbiology*
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Pneumonia, Viral / prevention & control
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Polymerase Chain Reaction*
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Predictive Value of Tests
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Viremia / microbiology*
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Virus Cultivation*