Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

D D Ho; A U Neumann; A S Perelson; W Chen; J M Leonard; M Markowitz

doi:10.1038/373123a0

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

Nature. 1995 Jan 12;373(6510):123-6. doi: 10.1038/373123a0.

Authors

D D Ho¹, A U Neumann, A S Perelson, W Chen, J M Leonard, M Markowitz

Affiliation

¹ Aaron Diamond AIDS Research Center, NYU School of Medicine, New York 10016.

PMID: 7816094
DOI: 10.1038/373123a0

Abstract

Treatment of infected patients with ABT-538, an inhibitor of the protease of human immunodeficiency virus type 1 (HIV-1), causes plasma HIV-1 levels to decrease exponentially (mean half-life, 2.1 +/- 0.4 days) and CD4 lymphocyte counts to rise substantially. Minimum estimates of HIV-1 production and clearance and of CD4 lymphocyte turnover indicate that replication of HIV-1 in vivo is continuous and highly productive, driving the rapid turnover of CD4 lymphocytes.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Antiviral Agents / therapeutic use
CD4 Lymphocyte Count / drug effects
CD4-Positive T-Lymphocytes / cytology
CD4-Positive T-Lymphocytes / virology*
HIV Infections / drug therapy
HIV Infections / immunology
HIV Infections / virology*
HIV Protease Inhibitors / therapeutic use
HIV-1 / physiology*
Humans
Kinetics
Ritonavir
Viremia / drug therapy
Viremia / virology*
Virion / physiology
Virus Replication*

Substances

Antiviral Agents
HIV Protease Inhibitors
Ritonavir