[Delay of the formation of retroperitoneal fibrosis after lymphadenectomy. An experimental study]

J Gynecol Obstet Biol Reprod (Paris). 1994;23(7):762-6.
[Article in French]

Abstract

The goal of our study was to evaluate peritoneal and retroperitoneal healing and therefore to assess the optimal date for surgery after laparoscopic lymphadenectomy. A para-aortic lymphadenectomy was carried out in 5 groups of 5 New Zealand female rabbits. The perivascular cicatricial tissue was dissected after specific delay for each group (48 hours, 1 week, 2 weeks, 4 weeks, and 6 weeks). Peritoneal reconstruction was observed in 80% of the "48 h" group, and in 100% in the other groups (from 1 to 6 weeks). Vascular injury complicated dissection in 40% for the "1 week" group, in 80% for the "2 weeks" group, and in 20% for the "6 weeks" group. No vascular complication was observed in the "48 h" and "4 weeks" groups. The results of "1 week" and "2 weeks" were combined. The results of the "4 weeks" group were compared, with the Fisher test, to the results of a "1 week" and "2 weeks" combined group as well as to the results of the "six weeks" group. Four weeks seem to be the optimal date for a possible surgical excision after a laparoscopic lymphadenectomy.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Adipose Tissue / pathology
  • Animals
  • Aorta / injuries
  • Cicatrix / pathology
  • Cicatrix / surgery
  • Collagen
  • Dissection
  • Edema / pathology
  • Female
  • Fibrosis
  • Laparoscopy / adverse effects*
  • Lymph Node Excision / adverse effects*
  • Peritoneal Diseases / pathology
  • Peritoneal Diseases / surgery
  • Peritoneum / pathology*
  • Peritoneum / surgery
  • Rabbits
  • Retroperitoneal Fibrosis / pathology
  • Retroperitoneal Fibrosis / prevention & control*
  • Time Factors
  • Wound Healing

Substances

  • Collagen