From July 1993 through June 1994, the authors performed 42 ultrasound (US)-guided core biopsies with use of a coaxial technique in which a 14- or 15-gauge core biopsy needle was passed through a 12-gauge introducer needle. This technique proved to be effective in all 42 biopsies. Use of the coaxial technique decreased the procedure time necessary for US-guided core biopsy and may be less traumatic than the standard core biopsy technique.