Abstract
Twenty one patients with resectable oral cancer received two courses of induction chemotherapy with peplomycin (PEP), vincristine (VCR), mitomycin C (MMC) and cisplatin (CDDP). Five patients had a complete response to the therapy and 9 had a partial response. Histological evaluation by Ohboshi-Shimozato classification indicated that Grade IV was obtained in 7 cases, Grade III was in 4 cases. Moreover, the study suggested that this regimen was less effective for metastatic lymph lesions than that for the primary tumors.
Publication types
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Clinical Trial
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English Abstract
MeSH terms
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Adult
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Aged
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Carcinoma, Squamous Cell / drug therapy*
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Carcinoma, Squamous Cell / pathology
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Cisplatin / administration & dosage
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Drug Administration Schedule
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Female
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Humans
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Lymphatic Metastasis
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Male
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Middle Aged
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Mitomycin / administration & dosage
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Mouth Neoplasms / drug therapy*
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Mouth Neoplasms / pathology
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Peplomycin / administration & dosage
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Vincristine / administration & dosage
Substances
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Mitomycin
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Peplomycin
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Vincristine
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Cisplatin