Abstract
A series of amidinosulfonic acids IIIa-f, analogs of taurine and homotaurine, was synthesized by reacting 2-aminoethane or 3-aminopropane sulfonic acid with lactim ethers Ia-c and then cyclized to sultams IVa-c and Vd-f. The effects of some selected amidinosulfonic acids III on membrane ionic conductances of rat skeletal muscle are described.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amidines / chemical synthesis
-
Amidines / pharmacology
-
Animals
-
In Vitro Techniques
-
Male
-
Muscle, Skeletal / drug effects*
-
Rats
-
Rats, Wistar
-
Structure-Activity Relationship
-
Sulfonic Acids / chemical synthesis
-
Sulfonic Acids / pharmacology
-
Taurine / analogs & derivatives*
-
Taurine / chemical synthesis*
-
Taurine / pharmacology
Substances
-
Amidines
-
Sulfonic Acids
-
Taurine
-
tramiprosate