Abstract
The effects of hydrocortisone administration (20 mg, orally, twice daily) on the sensitivity of brain 5-HT1A receptors in healthy volunteers were studied using a buspirone challenge paradigm. The effects of hydrocortisone administration on sleep architecture were also studied. Hydrocortisone treatment significantly attenuated the hypothermic and cortisol responses to buspirone; however, the prolactin and growth hormone responses were unchanged. Hydrocortisone also decreased the amount of rapid eye movement sleep (REM). The ability of hydrocortisone to attenuate 5-HT1A receptor mediated hypothermia and decrease REM sleep is shared by certain antidepressant treatments and may be related to the effects of corticosteroids on mood.
Publication types
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Clinical Trial
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Oral
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Adult
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Affect / drug effects
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Affect / physiology
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Body Temperature Regulation / drug effects
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Body Temperature Regulation / physiology
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Brain / drug effects*
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Brain / physiology
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Buspirone / pharmacology
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Dose-Response Relationship, Drug
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Double-Blind Method
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Drug Administration Schedule
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Growth Hormone / blood
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Humans
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Hydrocortisone / blood
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Hydrocortisone / pharmacology*
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Male
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Middle Aged
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Prolactin / blood
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Receptors, Serotonin / drug effects*
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Receptors, Serotonin / physiology
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Serotonin / physiology*
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Sleep Stages / drug effects*
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Sleep Stages / physiology
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Sleep, REM / drug effects
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Sleep, REM / physiology
Substances
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Receptors, Serotonin
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Serotonin
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Prolactin
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Growth Hormone
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Buspirone
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Hydrocortisone