Antiphospholipid and anti-beta 2 glycoprotein I antibodies in monozygotic twin sisters

J Rheumatol. 1994 Oct;21(10):1970-1.

Abstract

We describe an 18-year-old woman with primary antiphospholipid syndrome whose monozygotic twin sister is as yet an asymptomatic carrier of the lupus anticoagulant, anticardiolipin, and anti-beta 2 glycoprotein I (beta 2GPI) antibodies. Serum concentrations of beta 2GPI were normal in the patient and elevated in her sister. HLA and complement C4 phenotypes showed the presence of class II antigens DR7 and DRw53 and of a C4AQ0 allele. This supports the theory that a genetic predisposition may influence the appearance of these autoantibodies.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Alleles
  • Antibodies, Antiphospholipid / analysis*
  • Antibodies, Antiphospholipid / immunology
  • Antiphospholipid Syndrome / blood
  • Antiphospholipid Syndrome / genetics
  • Antiphospholipid Syndrome / immunology*
  • Autoantibodies / analysis*
  • Autoantibodies / immunology
  • Causality
  • Complement C4 / analysis
  • Complement C4 / genetics
  • Diseases in Twins*
  • Female
  • Glycoproteins / immunology*
  • HLA Antigens / analysis
  • HLA Antigens / blood
  • HLA Antigens / genetics
  • Humans
  • Twins, Monozygotic*
  • beta 2-Glycoprotein I

Substances

  • Antibodies, Antiphospholipid
  • Autoantibodies
  • Complement C4
  • Glycoproteins
  • HLA Antigens
  • beta 2-Glycoprotein I