FISH diagnosis of t(8;21) in a myelodysplasia secondary to Hodgkin lymphoma

Leukemia. 1995 Jan;9(1):107-8.

Abstract

A t(8;21)(q22;q22) translocation without blood and bone marrow invasion by immature myeloid precursors was suspected in a conventional karyotype and confirmed by fluorescence in situ hybridization (FISH) with chromosome 8 and 21 painting in a patient previously treated for Hodgkin's lymphoma. Six weeks later, the diagnosis was confirmed by the onset of acute myeloid leukemia (AML) M2 with a t(8;21) in the bone marrow.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosomes, Human, Pair 21*
  • Chromosomes, Human, Pair 8*
  • Hodgkin Disease / genetics*
  • Humans
  • In Situ Hybridization, Fluorescence*
  • Infant, Newborn
  • Leukemia, Myeloid, Acute / genetics*
  • Male
  • Translocation, Genetic*