Prognostic values of preoperative and postoperative CEA and CA19.9 levels in pancreatic cancer

Pancreas. 1994 Nov;9(6):735-40. doi: 10.1097/00006676-199411000-00011.

Abstract

Preoperative serum levels of carcinoembryonic antigen (CEA) and/or carbohydrate antigen 19.9 (CA19.9) were measured in 90 patients with advanced pancreatic cancer. CEA antigen was above the cutoff levels of 5.0 ng/ml in 51% of patients and CA19.9 was above the cutoff limit of 37 U/ml in 87% of patients. High preoperative CEA and CA19.9 levels were related to a poor prognosis of the patients. In multivariate analysis, the hazard rate was significantly higher in the high-CEA group (> 2.5 ng/ml) compared to the low-CEA group (< 2.4 ng/ml). An increase in CEA and/or CA19.9 within 1 month after the operation was also significantly related to the hazard rate. This study reconfirms the prognostic importance of preoperative and postoperative CEA and CA19.9.

Publication types

  • Comparative Study

MeSH terms

  • CA-19-9 Antigen / blood*
  • Carcinoembryonic Antigen / blood*
  • Humans
  • Immunoradiometric Assay
  • Multivariate Analysis
  • Neoplasm Staging
  • Pancreatic Neoplasms / blood*
  • Pancreatic Neoplasms / pathology
  • Pancreatic Neoplasms / surgery*
  • Postoperative Care
  • Preoperative Care
  • Prognosis
  • Radioimmunoassay
  • Sensitivity and Specificity

Substances

  • CA-19-9 Antigen
  • Carcinoembryonic Antigen