Abstract
1. Seven subjects with depression and matched controls were studied using proton spectroscopy to test the hypothesis that choline will be elevated in depression. 2. The proton spectroscopy was repeated after recovery from depression. 3. The study confirmed a state dependent increase in choline in the brain. 4. This change may be used as an in vivo marker of change in depression.
Publication types
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Clinical Trial
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aged
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Antidepressive Agents / therapeutic use*
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Aspartic Acid / analogs & derivatives
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Aspartic Acid / metabolism
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Brain Chemistry / drug effects
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Brain Chemistry / physiology*
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Choline / metabolism*
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Depressive Disorder / drug therapy
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Depressive Disorder / metabolism*
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Depressive Disorder / psychology
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Humans
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Image Processing, Computer-Assisted
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Magnetic Resonance Imaging
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Middle Aged
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Psychiatric Status Rating Scales
Substances
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Antidepressive Agents
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Aspartic Acid
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N-acetylaspartate
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Choline