A novel cytotoxic macrolide, superstolide B, related to superstolide A, from the New Caledonian marine sponge Neosiphonia superstes

M V D'Auria; L Gomez Paloma; L Minale; A Zampella; C Debitus

doi:10.1021/np50113a024

A novel cytotoxic macrolide, superstolide B, related to superstolide A, from the New Caledonian marine sponge Neosiphonia superstes

J Nat Prod. 1994 Nov;57(11):1595-7. doi: 10.1021/np50113a024.

Authors

M V D'Auria¹, L Gomez Paloma, L Minale, A Zampella, C Debitus

Affiliation

¹ Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, Italy.

PMID: 7853010
DOI: 10.1021/np50113a024

Abstract

The structure of a new cytotoxic macrolide, superstolide B [1], isolated from the deep water sponge Neosiphonia superstes, collected off New Caledonia, was elucidated mainly on the basis of nmr data. Compound 1 is closely related to superstolide A [2], a major cytotoxic component isolated from that organism, but lacks the 25-hydroxyl group found in 2 and has a C-24 (C-25)-double bond.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cytotoxins / chemistry*
Cytotoxins / isolation & purification
Macrolides*
Magnetic Resonance Spectroscopy
Molecular Conformation
Molecular Structure
New Caledonia
Porifera*
Structure-Activity Relationship
Tetrahydronaphthalenes / chemistry*
Tetrahydronaphthalenes / isolation & purification

Substances

Cytotoxins
Macrolides
Tetrahydronaphthalenes
superstolide A
superstolide B