Temporal lobe abnormalities in multigenerational families with schizophrenia

W G Honer; A S Bassett; G N Smith; J S Lapointe; P Falkai

doi:10.1016/0006-3223(94)90084-1

Temporal lobe abnormalities in multigenerational families with schizophrenia

Biol Psychiatry. 1994 Dec 1;36(11):737-43. doi: 10.1016/0006-3223(94)90084-1.

Authors

W G Honer¹, A S Bassett, G N Smith, J S Lapointe, P Falkai

Affiliation

¹ Department of Psychiatry, University of British Columbia, Vancouver, Canada.

Abstract

Brain structure in familial schizophrenia was studied with computerized tomography in 42 individuals from six multigenerational families. Sulcal enlargement in the lateral temporal cortex, and ventricular and cisternal enlargement in the medial temporal region were observed in psychotic individuals compared to unaffected family members. Genetic factors in familial schizophrenia may exert part of their effect through determining or altering temporal lobe structure.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Female
Functional Laterality
Humans
Male
Middle Aged
Schizophrenia / diagnostic imaging
Schizophrenia / genetics*
Schizophrenic Psychology*
Temporal Lobe / abnormalities*
Temporal Lobe / diagnostic imaging
Tomography, X-Ray Computed

Grants and funding

12155/Canadian Institutes of Health Research/Canada