Abstract
The gene encoding the human serotonin transporter (5-HTT) has been isolated and characterized. The human 5-HTT gene is composed of 14 exons spanning approximately 31 kb. The sequence of all exons including adjacent intronic sequences and a tandem repeat DNA polymorphism (VNTR) has been determined and deposited in the EMBL/GenBank data base with the accession numbers X76753 to X76762. The characterization of 5-HTT gene will aid to advance molecular pharmacologic studies of 5-HT uptake regulation and facilitate investigations of its role in psychiatric disorders.
MeSH terms
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Base Sequence
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Carrier Proteins / genetics*
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DNA, Complementary / genetics
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Exons
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Genes*
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Humans
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Introns
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Membrane Glycoproteins / genetics*
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Membrane Transport Proteins*
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Mental Disorders / genetics
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Minisatellite Repeats
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Molecular Sequence Data
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Nerve Tissue Proteins / genetics*
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Serotonin / metabolism
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Serotonin Plasma Membrane Transport Proteins
Substances
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Carrier Proteins
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DNA, Complementary
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Membrane Glycoproteins
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Membrane Transport Proteins
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Nerve Tissue Proteins
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SLC6A4 protein, human
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Serotonin Plasma Membrane Transport Proteins
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Serotonin
Associated data
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GENBANK/X76753
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GENBANK/X76762