Abstract
Intraperitoneal (IP) administration of bombesin (BBS; 2.5-20 micrograms/kg) induced a dose-dependent inhibition of food intake. The effect was decreased by intraventricular (ICV) administration of bombesin receptor antagonist [Leu14-psi (CH2NH)-Leu13] (3 micrograms/rat) but not by the D1 antagonist SCH 23390, the D2 antagonists sulpiride and pimozide, the dopamine antagonist cis-flupentixol, adrenoceptor blockers phenoxybenzamine or propranolol and serotonergic antagonist methergoline. It is concluded that BBS-induced suppression of feeding may be mediated through central BBS receptors, and is independent of interaction with brain catecholaminergic system.
MeSH terms
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Adrenergic alpha-Antagonists / pharmacology
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Adrenergic beta-Antagonists / pharmacology
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Amino Acid Sequence
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Animals
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Anorexia / chemically induced*
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Anorexia / psychology
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Bombesin / antagonists & inhibitors
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Bombesin / pharmacology*
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Catecholamines / physiology*
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Dopamine Antagonists / pharmacology
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Dose-Response Relationship, Drug
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Eating / drug effects
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Injections, Intraventricular
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Male
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Molecular Sequence Data
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Rats
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Receptors, Bombesin / antagonists & inhibitors
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Receptors, Bombesin / drug effects*
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Serotonin Antagonists / pharmacology
Substances
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Adrenergic alpha-Antagonists
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Adrenergic beta-Antagonists
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Catecholamines
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Dopamine Antagonists
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Receptors, Bombesin
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Serotonin Antagonists
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Bombesin