A fatal case of buflomedil self-poisoning: toxicological data and literature review

Forensic Sci Int. 1995 Jan 21;71(1):43-9. doi: 10.1016/0379-0738(94)01632-f.

Abstract

A fatal case of buflomedil (Fonzylane) self-poisoning is presented. Drug identification and quantification in postmortem blood, urine and gastric contents was achieved by means of high pressure liquid chromatography with diode-array detection (HPLC/DAD). Blood concentration was 275 micrograms/ml, > 70 times the usual therapeutic values. Toxicological results are discussed in the light of the existing literature.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adrenergic alpha-Antagonists / pharmacokinetics
  • Adrenergic alpha-Antagonists / poisoning*
  • Adult
  • Chromatography, High Pressure Liquid
  • Depressive Disorder / blood
  • Depressive Disorder / pathology
  • Gastrointestinal Contents / chemistry
  • Humans
  • Male
  • Postmortem Changes
  • Pyrrolidines / pharmacokinetics
  • Pyrrolidines / poisoning*
  • Suicide / legislation & jurisprudence*

Substances

  • Adrenergic alpha-Antagonists
  • Pyrrolidines
  • buflomedil