Rapid progression to disease in African sex workers with human immunodeficiency virus type 1 infection

O A Anzala; N J Nagelkerke; J J Bwayo; D Holton; S Moses; E N Ngugi; J O Ndinya-Achola; F A Plummer

doi:10.1093/infdis/171.3.686

Rapid progression to disease in African sex workers with human immunodeficiency virus type 1 infection

J Infect Dis. 1995 Mar;171(3):686-9. doi: 10.1093/infdis/171.3.686.

Authors

O A Anzala¹, N J Nagelkerke, J J Bwayo, D Holton, S Moses, E N Ngugi, J O Ndinya-Achola, F A Plummer

Affiliation

¹ Department of Medical Microbiology, University of Nairobi, Kenya.

PMID: 7876618
DOI: 10.1093/infdis/171.3.686

Abstract

From a cohort of female sex workers in Nairobi, Kenya, 163 women were observed to seroconvert to human immunodeficiency virus type 1 (HIV-1) and followed to study progression to HIV-1-related disease. The effect of several covariables on disease progression was studied using a Weibull proportional hazards model. The Weibull survival model was fitted to the observed incubation times. Estimates of the median duration to CDC stage IV-A and IV-C disease were 3.5 and 4.4 years, respectively. Condom use before seroconversion was associated with a reduced risk of CDC stage IV-A disease (relative risk = .64, P < .05). The incubation time of HIV-1-related disease is extremely short in this population.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acquired Immunodeficiency Syndrome / complications*
Adult
Female
Follow-Up Studies
HIV-1*
Humans
Sex Work*