The cytotoxic activity of Taxol in primary cultures of tumour cells from patients is partly mediated by Cremophor EL

P Nygren; K Csoka; B Jonsson; H Fridborg; J Bergh; H Hagberg; B Glimelius; O Brodin; B Tholander; A Kreuger

doi:10.1038/bjc.1995.97

The cytotoxic activity of Taxol in primary cultures of tumour cells from patients is partly mediated by Cremophor EL

Br J Cancer. 1995 Mar;71(3):478-81. doi: 10.1038/bjc.1995.97.

Authors

P Nygren¹, K Csoka, B Jonsson, H Fridborg, J Bergh, H Hagberg, B Glimelius, O Brodin, B Tholander, A Kreuger, et al.

Affiliation

¹ Department of Oncology, University Hospital, Uppsala University, Sweden.

Abstract

In patient tumour samples the activity in vitro of Taxol corresponded fairly well to the known clinical activity and Taxol showed low cross-resistance to standard cytotoxic drugs. However, the Taxol solvent Cremophor EL--ethanol was considerably active alone, whereas paclitaxel formulated in ethanol was less active. Taxol thus seems to contain two components active against patient tumour cells in vitro.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / toxicity
Drug Screening Assays, Antitumor
Drug Synergism
Fluorometry
Glycerol / analogs & derivatives*
Glycerol / pharmacology
Humans
Kinetics
Neoplasms / drug therapy*
Paclitaxel / toxicity*
Solvents / pharmacology
Tumor Cells, Cultured / drug effects

Substances

Antineoplastic Agents
Solvents
cremophor EL
Paclitaxel
Glycerol