Abstract
Spleen cells of C57B1/6 mice immunized twice with Schistosoma mansoni cercariae attenuated by ultraviolet irradiation proliferated and produced interleukin-(II)-2 and/or II-4 in response to both soluble schistosomular and adult worm antigens of 72-68, 60-62, 50, 45, 29.5 and 28 kDa. All of these bands, except the 45 kDa, were also recognized by serum antibodies in Western blotting.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigens, Helminth / immunology*
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B-Lymphocytes / immunology
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Female
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Interleukin-2 / biosynthesis
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Interleukin-4 / biosynthesis
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Larva / immunology
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Larva / radiation effects
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Mice
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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Protozoan Vaccines
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Schistosoma mansoni / immunology
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Schistosoma mansoni / radiation effects
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Schistosomiasis mansoni / immunology
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Schistosomiasis mansoni / prevention & control*
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Spleen / cytology
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Spleen / immunology*
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T-Lymphocytes / immunology
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Ultraviolet Rays
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Vaccination*
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Vaccines, Attenuated / immunology*
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Vaccines, Inactivated / immunology
Substances
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Antigens, Helminth
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Interleukin-2
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Protozoan Vaccines
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Vaccines, Attenuated
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Vaccines, Inactivated
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Interleukin-4