Abstract
Two cDNA sequences encoding rabbit carbonyl reductase (CBR) were cloned from a lambda gt10 rabbit liver cDNA library. The rabbit cDNAs coded for a protein with 84% identity to human CBR. Transient expression of the two rabbit cDNA sequences in COS7 cells increased both quinone reductase and aldo-keto reductase activities. These data demonstrate that CBR cDNAs from rabbit and human tissues code for similar proteins.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alcohol Oxidoreductases / biosynthesis*
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Alcohol Oxidoreductases / chemistry
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Alcohol Oxidoreductases / genetics*
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Aldehyde Reductase
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Aldo-Keto Reductases
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Amino Acid Sequence
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Animals
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Base Sequence
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Cells, Cultured
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Chlorocebus aethiops
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Cloning, Molecular
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DNA, Complementary / genetics
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Genes
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Humans
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Liver / enzymology*
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Molecular Sequence Data
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NAD(P)H Dehydrogenase (Quinone) / biosynthesis
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RNA, Messenger / analysis
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Rabbits
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Sequence Alignment
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Sequence Analysis, DNA
Substances
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DNA, Complementary
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RNA, Messenger
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Alcohol Oxidoreductases
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Aldo-Keto Reductases
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Aldehyde Reductase
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NAD(P)H Dehydrogenase (Quinone)
Associated data
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GENBANK/U07051
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GENBANK/U09244