Abstract
The role of coenzyme Q on the process of mitochondrial membrane damage associated with oxidative stress was studied in a suspension of uncoupled mitochondria exposed to Ca2+ in the presence of Fe(II)citrate or t-butyl hydroperoxide. Reduction of coenzyme Q by succinate was shown to inhibit both inner membrane lipid peroxidation and permeabilization induced by Fe(II)citrate. In contrast, the inner membrane permeabilization induced by Ca2+ alone or Ca2+ plus t-butyl hydroperoxide was potentiated by the presence of succinate. These results support our previous proposition that the mitochondrial damage associated with oxidative stress generated by these pro-oxidants in the presence of Ca2+ is mediated by different mechanisms.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antimycin A / pharmacology
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Butylated Hydroxytoluene / pharmacology
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Calcium / pharmacology*
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Citric Acid
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Ferrous Compounds / pharmacology*
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Free Radicals
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Mitochondria, Liver / drug effects*
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Mitochondrial Swelling / drug effects
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Oxidation-Reduction
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Oxidative Stress*
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Peroxides / pharmacology*
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Rats
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Rats, Wistar
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Succinates / metabolism
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Succinates / pharmacology
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Succinic Acid
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Thiobarbituric Acid Reactive Substances / metabolism
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Ubiquinone / metabolism*
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tert-Butylhydroperoxide
Substances
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Ferrous Compounds
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Free Radicals
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Peroxides
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Succinates
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Thiobarbituric Acid Reactive Substances
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Ubiquinone
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Butylated Hydroxytoluene
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Citric Acid
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ferrous citrate
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Antimycin A
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tert-Butylhydroperoxide
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Succinic Acid
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Calcium