To assess the ability of 3 established analysis methods in exercise stress electrocardiography to non-invasively detect the presence of coronary artery disease (CAD), 67 consecutive patients who had typical angina, positive exercise stress electrocardiography (ST segment depression > or = 1 mm) and coronary arteriography were studied. Thirty-three patients had significant CAD, and 34 had normal coronary arteriograms. The results showed that the Treadmill Score Method, utilising both ST and non-ST segment variables, had the highest accuracy in predicting disease. The predictive power of all 3 methods was lower in females.