Abstract
The effect of glutamine biosynthesis and degradation on glucose catabolism in Saccharomyces cerevisiae was studied. A wild-type strain and mutants altered in glutamine biosynthesis and degradation were analyzed. Cells having low levels of glutamine synthetase activity showed high ATP/ADP ratios and a diminished rate of glucose metabolism. It is proposed that glutamine biosynthesis plays a role in the regulation of glucose catabolism.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine Diphosphate / analysis
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Adenosine Triphosphate / analysis
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Carbon Dioxide / metabolism
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Glucose / metabolism*
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Glutamate-Ammonia Ligase / analysis
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Glutamine / biosynthesis*
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Mutation
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Saccharomyces cerevisiae / metabolism*
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Signal Transduction*
Substances
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Glutamine
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Carbon Dioxide
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Adenosine Diphosphate
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Adenosine Triphosphate
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Glutamate-Ammonia Ligase
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Glucose