Dose response in the treatment of breast cancer

Lancet. 1994 Feb 12;343(8894):402-4. doi: 10.1016/s0140-6736(94)91229-7.

Abstract

We present evidence that drugs that are effective in causing regression of metastatic breast cancer in a dose-dependent fashion also cause a dose-dependent reduction of cytokines produced by the immune system. This may be an important factor in the occasional induction of a complete remission.

MeSH terms

  • Bone Marrow Transplantation
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / immunology
  • Breast Neoplasms / secondary
  • Breast Neoplasms / therapy
  • Chemotherapy, Adjuvant
  • Cytokines / drug effects*
  • Dose-Response Relationship, Drug*
  • Female
  • Humans
  • Immunosuppression Therapy
  • Pregnanes / therapeutic use
  • Remission Induction

Substances

  • Cytokines
  • Pregnanes