Two cases of long term dopamine D2 receptor blockade after depot neuroleptics

J Neural Transm Gen Sect. 1993;94(3):217-21. doi: 10.1007/BF01277026.

Abstract

Two patients with extrapyramidal side effects after the use of fluphenazine decanoate were evaluated by means of IBZM-SPECT. Dopamine D2 receptor occupancy 1.5 months after withdrawal still amounted to 83% and 50%. More attention should be focused on long term effects of neuroleptics.

Publication types

  • Case Reports

MeSH terms

  • Antipsychotic Agents / administration & dosage
  • Antipsychotic Agents / adverse effects*
  • Antipsychotic Agents / therapeutic use
  • Basal Ganglia Diseases / chemically induced
  • Basal Ganglia Diseases / physiopathology
  • Delayed-Action Preparations
  • Dopamine D2 Receptor Antagonists*
  • Female
  • Fluphenazine / adverse effects
  • Fluphenazine / analogs & derivatives
  • Fluphenazine / therapeutic use
  • Humans
  • Male
  • Middle Aged
  • Schizophrenia, Paranoid / complications
  • Schizophrenia, Paranoid / drug therapy
  • Tomography, Emission-Computed, Single-Photon

Substances

  • Antipsychotic Agents
  • Delayed-Action Preparations
  • Dopamine D2 Receptor Antagonists
  • fluphenazine depot
  • Fluphenazine