Antipsychotic maintenance treatment of schizophrenia patients: is there a consensus?

Schizophr Bull. 1994;20(1):215-25. doi: 10.1093/schbul/20.1.215.

Abstract

We obtained pharmaco-epidemiologic data regarding the antipsychotic maintenance treatment (AMT) of schizophrenia patients through a postal survey sent to all Austrian psychiatrists and neurologists. Drug therapy was considered the most important therapeutic approach in the long-term management of schizophrenia. However, the majority of the respondents clearly were not satisfied with the current status of scientific knowledge about dosage and duration of AMT. Single-drug treatment with antipsychotics was preferred by the respondents; oral and depot neuroleptics were used with equal frequency. Haloperidol was the oral drug most frequently mentioned as first choice (44% of the respondents), followed by clozapine (14.1%) and thioridazine (9.2%). The proposed mean daily doses showed striking variations among respondents. The proposed mean length of maintenance treatment in first-episode patients was 7.3 months; in multi-episode patients, it was 20.1 months. The results show considerable variation in physicians' attitudes toward AMT.

MeSH terms

  • Administration, Oral
  • Antipsychotic Agents / adverse effects
  • Antipsychotic Agents / therapeutic use*
  • Attitude of Health Personnel*
  • Delayed-Action Preparations
  • Dose-Response Relationship, Drug
  • Drug Therapy, Combination
  • Drug Utilization
  • Hospitals, Psychiatric
  • Humans
  • Long-Term Care
  • Patient Care Team*
  • Private Practice
  • Schizophrenia / diagnosis
  • Schizophrenia / drug therapy*
  • Schizophrenic Psychology*

Substances

  • Antipsychotic Agents
  • Delayed-Action Preparations