Abstract
One commonly studied model system for peripheral tolerance is the antigen-specific unresponsiveness of T cells from mice previously inoculated with superantigens such as Mls-1a. In this study, we used a TcR V beta 8.1 transgenic mouse model to investigate whether mice peripherally tolerized to Mls-1a exhibit delayed skin allograft rejection. We report dramatic prolongation of skin allograft survival in V beta 8.1 transgenic but not in non-transgenic mice tolerized to Mls-1a. Peripherally induced unresponsiveness to Mls-1a can, therefore, be considered true tolerance.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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CD4-Positive T-Lymphocytes / immunology
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Cells, Cultured
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Cytotoxicity Tests, Immunologic
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Graft Rejection / immunology*
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Immune Tolerance / immunology*
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Lymphokines / immunology
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Mice
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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Mice, Inbred CBA
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Mice, Transgenic
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Minor Lymphocyte Stimulatory Antigens / immunology*
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Receptors, Antigen, T-Cell, alpha-beta / immunology*
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Skin Transplantation / immunology*
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Spleen / cytology
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T-Lymphocytes, Cytotoxic / immunology
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Transplantation
Substances
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Lymphokines
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Minor Lymphocyte Stimulatory Antigens
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Receptors, Antigen, T-Cell, alpha-beta