Abstract
gamma-Pyrone-3-acetic acid (L-741,494) is a novel metabolite produced by a culture of the fungal genus Xylaria. This substance is a water-soluble, competitive, irreversible inhibitor of Interleukin-1 beta Converting Enzyme that is inactive against papain and trypsin. It has a mol wt of 154 and an empirical formula of C7H6O4. We propose the name xylaric acid for this compound.
MeSH terms
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Acetates / chemistry
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Acetates / isolation & purification
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Acetates / pharmacology*
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Amino Acid Sequence
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Caspase 1
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Chromatography, Ion Exchange
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Cysteine Endopeptidases / chemistry*
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Magnetic Resonance Spectroscopy
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Metalloendopeptidases / chemistry*
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Molecular Sequence Data
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Pyrones / chemistry
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Pyrones / isolation & purification
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Pyrones / pharmacology*
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Xylariales / metabolism*
Substances
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Acetates
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L 741494
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Pyrones
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Cysteine Endopeptidases
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Caspase 1
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Metalloendopeptidases