The apolipoprotein E allele epsilon 4 is overrepresented in patients with the Lewy body variant of Alzheimer's disease

Neurology. 1994 Oct;44(10):1950-1. doi: 10.1212/wnl.44.10.1950.

Abstract

We determined apolipoprotein E (ApoE) genotypes in 122 autopsied demented patients. The frequency of the ApoE epsilon 4 allele was 39.6% in Alzheimer's disease (AD), 29.0% in the Lewy body variant of AD (LBV), and 6.25% in diffuse Lewy body disease. For AD and LBV patients, the epsilon 4 frequency was significantly higher than that reported in nondemented controls (10 to 15%). Therefore, LBV and AD share ApoE epsilon 4 as a genetic risk factor, providing further evidence that these conditions overlap.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alleles*
  • Alzheimer Disease / genetics*
  • Alzheimer Disease / pathology
  • Apolipoproteins E / genetics*
  • Female
  • Gene Frequency
  • Genotype
  • Humans
  • Lewy Bodies*
  • Male
  • Risk Factors

Substances

  • Apolipoproteins E