Structure-antifilarial activity relationship of 5/6/7/8-mono- or disubstituted 1H/1-phenyl-9H-pyrido[3,4-b]indoles--a new class of potential filaricides

A Agarwal; S K Agarwal; S N Singh; N Fatma; R K Chatterjee

doi:10.1515/znc-1994-7-821

Structure-antifilarial activity relationship of 5/6/7/8-mono- or disubstituted 1H/1-phenyl-9H-pyrido[3,4-b]indoles--a new class of potential filaricides

Z Naturforsch C J Biosci. 1994 Jul-Aug;49(7-8):526-9. doi: 10.1515/znc-1994-7-821.

Authors

A Agarwal¹, S K Agarwal, S N Singh, N Fatma, R K Chatterjee

Affiliation

¹ Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow, India.

PMID: 7945675
DOI: 10.1515/znc-1994-7-821

Abstract

Antifilarial activity of 5/6/7/8-mono- or disubstituted 1 H/1-phenyl-9H-pyrido[3,4-b]indoles (I) has been described. The 1,6- and 8-substituted 9H-pyrido[3,4-b]indoles (I) elicited interesting filaricidal activity against Litomosoides carinii and Acanthocheilonema viteae in rodent hosts.

Publication types

Comparative Study

MeSH terms

Animals
Dipetalonema / drug effects*
Filaricides / chemistry
Filaricides / pharmacology*
Filarioidea / drug effects*
Indoles / chemistry
Indoles / pharmacology*
Molecular Structure
Muridae
Sigmodontinae
Structure-Activity Relationship

Substances

Filaricides
Indoles