Insulin-resistant diabetes during growth hormone therapy in a child with SHORT syndrome

Acta Paediatr. 1994 Jul;83(7):786-8. doi: 10.1111/j.1651-2227.1994.tb13142.x.

Abstract

We report the case of a 13-year-old boy with SHORT syndrome, including lipoatrophy and insulin resistance, who developed diabetes mellitus while receiving growth hormone therapy. The diabetes persisted after cessation of exogenous growth hormone but oral hypoglycaemic therapy was successful and could be discontinued eight months later.

Publication types

  • Case Reports

MeSH terms

  • Abnormalities, Multiple / drug therapy*
  • Anodontia / complications*
  • Blood Glucose / analysis
  • Child
  • Diabetes Mellitus, Lipoatrophic / blood
  • Diabetes Mellitus, Lipoatrophic / chemically induced*
  • Diabetes Mellitus, Lipoatrophic / drug therapy
  • Eye Abnormalities / complications*
  • Facial Bones / abnormalities*
  • Growth Disorders / complications
  • Growth Disorders / diagnosis
  • Growth Disorders / drug therapy*
  • Growth Hormone / adverse effects*
  • Humans
  • Insulin / blood
  • Insulin Resistance*
  • Male
  • Metformin / therapeutic use
  • Syndrome

Substances

  • Blood Glucose
  • Insulin
  • Growth Hormone
  • Metformin