Acute arterial thrombosis in a patient with breast cancer after chemotherapy with 5-fluorouracil, doxorubicin, leucovorin, cyclophosphamide, and interleukin-3

Cancer. 1994 Nov 15;74(10):2808-10. doi: 10.1002/1097-0142(19941115)74:10<2808::aid-cncr2820741011>3.0.co;2-v.

Abstract

Background: Interleukin-3 (IL-3) is an experimental agent used to ameliorate neutropenia in patients receiving chemotherapy. Arterial thrombotic episodes after use of IL-3 have not been reported previously.

Methods: The case of a patient with Stage III adenocarcinoma of the breast who developed hypotension and acute cerebellar artery and superior mesenteric artery thrombosis after receiving chemotherapy and treatment with IL-3 is reported.

Results: To the authors' knowledge, this is the first patient with arterial thrombosis reported after treatment with IL-3.

Conclusions: Interleukin-3 may be associated with increased propensity for thrombosis.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Adenocarcinoma / drug therapy*
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Breast Neoplasms / drug therapy*
  • Cerebellum / blood supply
  • Cyclophosphamide / administration & dosage
  • Doxorubicin / administration & dosage
  • Female
  • Fluorouracil / administration & dosage
  • Humans
  • Interleukin-3 / adverse effects*
  • Intracranial Embolism and Thrombosis / chemically induced
  • Leucovorin / administration & dosage
  • Mesenteric Artery, Superior
  • Middle Aged
  • Myeloproliferative Disorders / chemically induced
  • Myeloproliferative Disorders / prevention & control*
  • Thrombosis / chemically induced*

Substances

  • Interleukin-3
  • Doxorubicin
  • Cyclophosphamide
  • Leucovorin
  • Fluorouracil