Abstract
Twenty-one cynomolgus monkeys were immunized with whole inactivated HIV-2 preparations administered with various adjuvants (incomplete Freund's adjuvant, Alum, Ribi, MDP, or Iscoms) and challenged with 10 or 100 MID50 of a homologous monkey-cell grown, cell-free HIV-2. Seven animals were completely protected against infection, three showed reduced virus replication. The vaccines elicited neutralizing and ADCC antibodies; the titers did not correlate with protection. Immunization with a whole inactivated vaccine can protect primates from intravenous challenge with a monkey-cell grown cell-free human immunodeficiency virus type 2.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
AIDS Vaccines / immunology*
-
Acquired Immunodeficiency Syndrome / immunology*
-
Acquired Immunodeficiency Syndrome / prevention & control
-
Adjuvants, Immunologic
-
Animals
-
Antibody-Dependent Cell Cytotoxicity
-
Cell Line
-
Female
-
Genes, env
-
Genes, gag
-
Genes, pol
-
HIV Antibodies / blood*
-
HIV Long Terminal Repeat
-
HIV-2 / immunology*
-
HIV-2 / isolation & purification
-
HIV-2 / physiology
-
Lymph Nodes / virology
-
Lymphocytes / virology
-
Macaca fascicularis
-
Male
-
Polymerase Chain Reaction / methods
-
Vaccines, Inactivated / immunology*
-
Virus Replication
Substances
-
AIDS Vaccines
-
Adjuvants, Immunologic
-
HIV Antibodies
-
Vaccines, Inactivated