Abstract
In this study, the cytokine-producing profile of progenitor T cells (pro-T cells) was determined. During screening of a complementary DNA library generated from activated mouse pro-T cells, a cytokine designated lymphotactin was discovered. Lymphotactin is similar to members of both the Cys-Cys and Cys-X-Cys chemokine families but lacks two of the four cysteine residues that are characteristic of the chemokines. Lymphotactin is also expressed in activated CD8+ T cells and CD4-CD8- T cell receptor alpha beta + thymocytes. It has chemotactic activity for lymphocytes but not for monocytes or neutrophils. The gene encoding lymphotactin maps to chromosome one. Taken together, these observations suggest that lymphotactin represents a novel addition to the chemokine superfamily.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Calcium / metabolism
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Cell Line
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Chemokine CCL4
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Chemokines, C*
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Chemotaxis, Leukocyte*
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Cytokines / pharmacology
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Hematopoietic Stem Cells / immunology*
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Humans
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Lymphokines / chemistry
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Lymphokines / genetics
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Lymphokines / isolation & purification
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Lymphokines / pharmacology
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Lymphokines / physiology*
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Macrophage Inflammatory Proteins
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Mice
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Mice, Inbred BALB C
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Molecular Sequence Data
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Monokines / pharmacology
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Recombinant Proteins
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Sequence Alignment
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Sialoglycoproteins / chemistry
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Sialoglycoproteins / genetics
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Sialoglycoproteins / isolation & purification
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Sialoglycoproteins / pharmacology
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Sialoglycoproteins / physiology*
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Signal Transduction
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T-Lymphocyte Subsets / immunology*
Substances
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Chemokine CCL4
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Chemokines, C
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Cytokines
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Lymphokines
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Macrophage Inflammatory Proteins
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Monokines
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Recombinant Proteins
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Sialoglycoproteins
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XCL1 protein, human
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Xcl1 protein, mouse
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lymphotactin
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Calcium