Effectiveness of high-dose intravenous gamma globulin therapy in acquired von Willebrand's disease

Vox Sang. 1994;67(1):14-7. doi: 10.1111/j.1423-0410.1994.tb05030.x.

Abstract

An 82-year-old patient with acquired von Willebrand's disease in association with a non-Hodgkin's lymphoma and a benign IgG-lambda monoclonal paraproteinemia is described with severe recurring nasopharyngeal bleedings, who responded poorly to desmopressin (DDAVP) and factor VIII/von Willebrand factor concentrates but was successfully treated with high-dose e intravenous gamma-globulin therapy.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Aged, 80 and over
  • Autoantibodies / immunology
  • Autoimmune Diseases / etiology
  • Autoimmune Diseases / therapy*
  • Deamino Arginine Vasopressin / therapeutic use
  • Factor VIII / therapeutic use
  • Hemorrhage / etiology
  • Hemorrhage / prevention & control
  • Humans
  • Immunoglobulin M / immunology
  • Immunoglobulin lambda-Chains
  • Immunoglobulins, Intravenous / therapeutic use*
  • Lymphoma, B-Cell / complications
  • Lymphoma, Non-Hodgkin / complications
  • Male
  • Monoclonal Gammopathy of Undetermined Significance / complications
  • von Willebrand Diseases / etiology
  • von Willebrand Diseases / therapy*
  • von Willebrand Factor / immunology

Substances

  • Autoantibodies
  • Immunoglobulin M
  • Immunoglobulin lambda-Chains
  • Immunoglobulins, Intravenous
  • von Willebrand Factor
  • Factor VIII
  • Deamino Arginine Vasopressin