Abstract
The hepatitis B virus enhancer 1 contains a retinoic acid responsive element (RARE). We have previously demonstrated that retinoid X receptor alpha (RXR alpha) transactivates enhancer 1 by binding to the RARE. The present study has revealed that a heterodimeric complex composed of RXR alpha and peroxisome proliferator-activated receptor (PPAR) interacts with the hepatitis B virus RARE. Transient transfection studies, in conjunction with in vitro DNA binding data, support the hypothesis that the RXR alpha-PPAR heterodimer transactivates enhancer 1.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Base Sequence
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Enhancer Elements, Genetic*
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Hepatitis B virus / genetics*
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Molecular Sequence Data
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Nuclear Proteins / physiology*
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Receptors, Cytoplasmic and Nuclear / metabolism*
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Receptors, Retinoic Acid / physiology*
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Retinoid X Receptors
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Transcription Factors / metabolism*
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Transcription Factors / physiology*
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Transcriptional Activation*
Substances
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Nuclear Proteins
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Receptors, Cytoplasmic and Nuclear
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Receptors, Retinoic Acid
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Retinoid X Receptors
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Transcription Factors