[The role of phosphorylation cascade in insulin action]

K Tobe; K Ueki; H Tamemoto; Y Kaburagi; R Honda; T Kadowaki

[The role of phosphorylation cascade in insulin action]

Nihon Rinsho. 1994 Oct;52(10):2673-85.

[Article in Japanese]

Authors

K Tobe¹, K Ueki, H Tamemoto, Y Kaburagi, R Honda, T Kadowaki

Affiliation

¹ Internal Medicine III, Faculty of Medicine, University of Tokyo.

PMID: 7983797

Abstract

Insulin induces a wide variety of growth and metabolic response in many cell types. Insulin initiates its biological effects by activation of tyrosine kinase in the beta-subunit and phosphorylates several proteins, such as insulin receptor substrate-1 (IRS-1), Shc. thereby activating phosphatidyl inositol 3-kinase activity, and ras activity. MAP kinase cascade activated by ras, 70kDaS6 kinase lying downstream of PI3-kinase, and the regulation of glycogen synthase have been discussed.

Publication types

English Abstract
Review

MeSH terms

Animals
Glycogen Synthase / metabolism
Insulin / physiology*
Insulin Receptor Substrate Proteins
Liver / metabolism
Phosphatidylinositol 3-Kinases
Phosphoproteins / metabolism
Phosphorylation
Phosphotransferases (Alcohol Group Acceptor) / metabolism
Protein-Tyrosine Kinases / metabolism
Signal Transduction

Substances

Insulin
Insulin Receptor Substrate Proteins
Phosphoproteins
Glycogen Synthase
Phosphatidylinositol 3-Kinases
Phosphotransferases (Alcohol Group Acceptor)
Protein-Tyrosine Kinases