Trisomy 11 and other nonrandom trisomies in congenital fibrosarcoma

R Bernstein; P M Zeltzer; F Lin; P M Carpenter

doi:10.1016/0165-4608(94)90051-5

Trisomy 11 and other nonrandom trisomies in congenital fibrosarcoma

Cancer Genet Cytogenet. 1994 Nov;78(1):82-6. doi: 10.1016/0165-4608(94)90051-5.

Authors

R Bernstein¹, P M Zeltzer, F Lin, P M Carpenter

Affiliation

¹ Division of Human Genetics, College of Medicine, University of California, Irvine.

PMID: 7987812
DOI: 10.1016/0165-4608(94)90051-5

Abstract

Chromosome studies in a 7-week-old female infant with an intraabdominal malignant fibrosarcoma showed a hyperdiploid karyotype of 50,XX, +der(6)del(6)(p23)add(6)(q11), +8, +10, +11,add(12)(p13). Trisomy 11 appears to be a nonrandom primary cytogenetic abnormality in the congenital or infantile form of this mesenchymal tumor and is also a nonrandom gain in congenital mesoblastic nephroma. A possible developmental link between these two mesenchymal tumors, mediated by a gene or genes on chromosome 11 is postulated.

Publication types

Case Reports

MeSH terms

Chromosomes, Human, Pair 11*
Female
Fibrosarcoma / congenital
Fibrosarcoma / genetics*
Humans
Immunoenzyme Techniques
Infant
Karyotyping
Soft Tissue Neoplasms / congenital
Soft Tissue Neoplasms / genetics*
Trisomy*