Abstract
The synthesis of the glycosyl-myo-inositol 1-phosphates 1 and 2 and of the glycosyl-myo-inositol 1,2-(cyclic phosphate) 3, starting from previously synthesized intermediates, is reported. Compound 3 was found to display proliferative effects on the early developing inner ear of chick embryo.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Chick Embryo
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DNA / biosynthesis
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Ear / embryology*
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Glucosamine / analogs & derivatives*
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Glucosamine / chemical synthesis
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Glucosamine / pharmacology
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Glycosylphosphatidylinositols / metabolism
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Inositol Phosphates / chemical synthesis
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Inositol Phosphates / pharmacology*
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Insulin / metabolism*
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Organ Culture Techniques
Substances
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4-O-(2-amino-2-deoxyglucopyranosyl)inositol 1-phosphate
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6-O-(2-amino-2-deoxy-D-glucopyranosyl)inositol 1,2-(cyclic phosphate)
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6-O-(2-amino-2-deoxyglucopyranosyl)inositol 1-phosphate
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Glycosylphosphatidylinositols
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Inositol Phosphates
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Insulin
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DNA
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Glucosamine