Synthesis and investigation of the possible insulin-like activity of 1D-4-O- and 1D-6-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-myo-inositol 1-phosphate and 1D-6-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-myo-inositol 1,2-(cyclic phosphate)

Carbohydr Res. 1994 Nov 1;264(1):21-31. doi: 10.1016/0008-6215(94)00178-2.

Abstract

The synthesis of the glycosyl-myo-inositol 1-phosphates 1 and 2 and of the glycosyl-myo-inositol 1,2-(cyclic phosphate) 3, starting from previously synthesized intermediates, is reported. Compound 3 was found to display proliferative effects on the early developing inner ear of chick embryo.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chick Embryo
  • DNA / biosynthesis
  • Ear / embryology*
  • Glucosamine / analogs & derivatives*
  • Glucosamine / chemical synthesis
  • Glucosamine / pharmacology
  • Glycosylphosphatidylinositols / metabolism
  • Inositol Phosphates / chemical synthesis
  • Inositol Phosphates / pharmacology*
  • Insulin / metabolism*
  • Organ Culture Techniques

Substances

  • 4-O-(2-amino-2-deoxyglucopyranosyl)inositol 1-phosphate
  • 6-O-(2-amino-2-deoxy-D-glucopyranosyl)inositol 1,2-(cyclic phosphate)
  • 6-O-(2-amino-2-deoxyglucopyranosyl)inositol 1-phosphate
  • Glycosylphosphatidylinositols
  • Inositol Phosphates
  • Insulin
  • DNA
  • Glucosamine