New nematicidal and antimicrobial compounds from the basidiomycete Cheimonophyllum candidissimum (Berk & Curt.) sing. I. Producing organism, fermentation, isolation, and biological activities

M Stadler; H Anke

doi:10.7164/antibiotics.47.1284

New nematicidal and antimicrobial compounds from the basidiomycete Cheimonophyllum candidissimum (Berk & Curt.) sing. I. Producing organism, fermentation, isolation, and biological activities

J Antibiot (Tokyo). 1994 Nov;47(11):1284-9. doi: 10.7164/antibiotics.47.1284.

Authors

M Stadler¹, H Anke

Affiliation

¹ Lehrbereich Biotechnologie, University of Kaiserslautern, Federal Republic of Germany.

PMID: 8002392
DOI: 10.7164/antibiotics.47.1284

Abstract

Six new bisabolane type sesquiterpenoids, cheimonophyllons A (1), B (2), C (3), D (4), E (5), and cheimonophyllal (6) were isolated from the culture fluid of the basidiomycete, Cheimonophyllum candidissimum. The compounds exhibited nematicidal, weak antifungal and antibacterial as well as cytotoxic activities. The main product, cheimonophyllon A (1) (C15H22O4), was also active in the Ames mutagenicity test.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Bacterial Agents / isolation & purification*
Anti-Bacterial Agents / pharmacology
Antinematodal Agents / isolation & purification*
Antinematodal Agents / pharmacology
Basidiomycota / metabolism*
Cattle
Cell Line
Cell Survival / drug effects
Fermentation
Sesquiterpenes / isolation & purification*
Sesquiterpenes / pharmacology

Substances

Anti-Bacterial Agents
Antinematodal Agents
Sesquiterpenes