Administration of neomycin-resistance-gene-marked EBV-specific cytotoxic T lymphocytes to recipients of mismatched-related or phenotypically similar unrelated donor marrow grafts

Hum Gene Ther. 1994 Mar;5(3):381-97. doi: 10.1089/hum.1994.5.3-381.
No abstract available

Publication types

  • Clinical Trial
  • Clinical Trial, Phase I

MeSH terms

  • Adult
  • Biomarkers
  • Bone Marrow Transplantation / adverse effects*
  • Cell Line
  • Child
  • Clinical Protocols
  • Cytotoxicity, Immunologic
  • Drug Resistance / genetics
  • Female
  • Genetic Vectors
  • Graft vs Host Disease / prevention & control
  • Herpesviridae Infections / prevention & control*
  • Herpesviridae Infections / transmission
  • Herpesvirus 4, Human* / growth & development
  • Herpesvirus 4, Human* / immunology
  • Humans
  • Immunocompromised Host
  • Incidence
  • Informed Consent
  • Kanamycin Kinase
  • Leukemia / surgery
  • Lymphoma, Non-Hodgkin / surgery
  • Lymphoproliferative Disorders / epidemiology
  • Lymphoproliferative Disorders / microbiology
  • Lymphoproliferative Disorders / prevention & control*
  • Male
  • Moloney murine leukemia virus / genetics
  • Myelodysplastic Syndromes / surgery
  • Neomycin / pharmacology
  • Phosphotransferases (Alcohol Group Acceptor) / biosynthesis
  • Phosphotransferases (Alcohol Group Acceptor) / genetics*
  • Recombinant Fusion Proteins / biosynthesis
  • Recombinant Fusion Proteins / genetics*
  • Safety
  • T-Lymphocytes, Cytotoxic / drug effects
  • T-Lymphocytes, Cytotoxic / immunology
  • T-Lymphocytes, Cytotoxic / transplantation*
  • Tissue Donors
  • Transplantation, Homologous
  • Tumor Virus Infections / prevention & control*
  • Tumor Virus Infections / transmission
  • Virus Activation* / immunology

Substances

  • Biomarkers
  • Recombinant Fusion Proteins
  • Phosphotransferases (Alcohol Group Acceptor)
  • Kanamycin Kinase
  • Neomycin