Abstract
1. Immature mice were induced to ovulate by pregnant serum gonadotropin and human chorionic gonadotropin. 2. The ribosome inactivating proteins luffaculin, luffin-a, luffin-b and momorcochin were administered i.p. 3. It was found that all four ribosome inactivating proteins elicited a reduction in the circulating titer of estradiol-17 beta. 4. Both luffaculin and momorcochin brought about an increase in the number of degenerated oocytes. 5. Only momorcochin caused a decrease in the ovarian weight and the number of ovulated oocytes.
MeSH terms
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Animals
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Chorionic Gonadotropin / pharmacology
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Estradiol / blood*
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Female
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Glycoproteins / pharmacology
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Gonadotropins, Equine / pharmacology
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Mice
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Mice, Inbred ICR
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Oocytes / drug effects
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Oocytes / physiology
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Organ Size / drug effects
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Ovary / anatomy & histology
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Ovary / drug effects
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Ovulation / drug effects*
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Ovulation Induction
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Plant Proteins / pharmacology*
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Ribosomal Proteins / antagonists & inhibitors
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Ribosome Inactivating Proteins, Type 1
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Ribosomes / drug effects
Substances
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Chorionic Gonadotropin
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Glycoproteins
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Gonadotropins, Equine
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Plant Proteins
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Ribosomal Proteins
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Ribosome Inactivating Proteins, Type 1
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luffin-a protein, Luffa cylindrica
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luffin-b protein, Luffa cylindrica
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Estradiol