Abstract
1. alpha-Momorcharin, a glycoprotein isolated from seeds of the bitter gourd, Momordica charantia inhibited incorporation of [3H]thymidine, [3H]leucine and [3H]uridine into P388 (mouse monocyte-macrophage), J774 (Balb/c macrophage), JAR (human placental choriocarcinoma) and sarcoma S180 cell lines. 2. The most potent inhibitory effect was exerted on P388 cells and the smallest effect on sarcoma cells. 3. alpha-Momorcharin also enhanced the tumoricidal effect of mouse macrophages on mouse mastocytomal (P815) cells.
MeSH terms
-
Animals
-
Antineoplastic Agents, Phytogenic / pharmacology*
-
Drug Screening Assays, Antitumor
-
Humans
-
Leucine / metabolism
-
Leukemia P388 / drug therapy
-
Leukemia P388 / metabolism
-
Macrophages / drug effects
-
Macrophages / metabolism
-
Mast-Cell Sarcoma / drug therapy
-
Mast-Cell Sarcoma / metabolism
-
Mice
-
Mice, Inbred BALB C
-
Monocytes / drug effects
-
Monocytes / metabolism
-
Plant Extracts / pharmacology
-
Plant Proteins / pharmacology*
-
Ribosomal Proteins*
-
Ribosome Inactivating Proteins
-
Sarcoma 180 / drug therapy
-
Sarcoma 180 / metabolism
-
Thymidine / metabolism
-
Tritium
-
Tumor Cells, Cultured / drug effects
-
Uridine / metabolism
Substances
-
Antineoplastic Agents, Phytogenic
-
Plant Extracts
-
Plant Proteins
-
Ribosomal Proteins
-
Tritium
-
MMC protein, Momordica charantia
-
Ribosome Inactivating Proteins
-
Leucine
-
Thymidine
-
Uridine