Abstract
Metronidazole-susceptible pretreatment isolates and metronidazole-resistant posttreatment isolates of Helicobacter pylori from 11 patients before and after unsuccessful triple therapy consisting of metronidazole, amoxicillin, and colloidal bismuth subcitrate were studied. Ribotyping (rRNA gene restriction pattern analysis) of the isolates demonstrated that all patients except one had identical digest patterns for pre- and posttreatment isolates.
MeSH terms
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Amoxicillin / administration & dosage
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Anti-Ulcer Agents / administration & dosage
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DNA, Bacterial / genetics*
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DNA, Ribosomal / genetics
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Drug Resistance, Microbial / genetics
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Drug Therapy, Combination
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Gastritis / drug therapy
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Gastritis / microbiology
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Helicobacter Infections / drug therapy
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Helicobacter Infections / microbiology
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Helicobacter pylori / drug effects*
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Helicobacter pylori / genetics*
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Helicobacter pylori / isolation & purification
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Humans
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Metronidazole / administration & dosage
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Metronidazole / pharmacology*
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Organometallic Compounds / administration & dosage
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Peptic Ulcer / drug therapy
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Peptic Ulcer / microbiology
Substances
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Anti-Ulcer Agents
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DNA, Bacterial
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DNA, Ribosomal
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Organometallic Compounds
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Metronidazole
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Amoxicillin
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bismuth tripotassium dicitrate