Necrosis in a meningioma following systemic chemotherapy. Case report

J Neurosurg. 1994 Aug;81(2):284-7. doi: 10.3171/jns.1994.81.2.0284.

Abstract

Radiological and clinical evidence of acute necrosis in a meningioma following one cycle of chemotherapy with 5-fluorouracil, folinic acid, and levamisole was observed in a patient being treated for invasive rectal carcinoma. The possible mechanisms and implications of this occurrence are discussed.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / drug therapy*
  • Adenocarcinoma / radiotherapy
  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Combined Modality Therapy
  • Embolization, Therapeutic
  • Fluorouracil / administration & dosage
  • Humans
  • Leucovorin / administration & dosage
  • Levamisole / administration & dosage
  • Male
  • Meningeal Neoplasms / pathology*
  • Meningeal Neoplasms / surgery
  • Meningeal Neoplasms / therapy
  • Meningioma / pathology*
  • Meningioma / surgery
  • Meningioma / therapy
  • Middle Aged
  • Necrosis
  • Neoplasms, Multiple Primary / pathology*
  • Radiotherapy Dosage
  • Rectal Neoplasms / drug therapy*
  • Rectal Neoplasms / radiotherapy

Substances

  • Levamisole
  • Leucovorin
  • Fluorouracil