Seven cases of empty sella syndrome were reported, among them 2 cases were primary empty sella syndrome, 5 cases were secondary empty sella syndrome. 5 cases were operated with the obliteration by transsphenoidal approach, 2 cases were operated by transfrontal approach. 6 cases were cured, the symptoms in one case was not improved due to the primary hydrocephalus. This syndrome is associated with defect of sellar diaphragm, benign intracranial hypertension, long-term administration of Bromocriptine, surgery and radiotherapy of pituitary gland. Main clinical features are headache, damage of vision and visual fields, hypopituitarism. Obliteration of empty sella by transsphenoidal approach is a simple and effective method.