Abstract
The structures of new antibiotics, shurimycins A and B produced by Streptomyces hygroscopicus A1491, were elucidated from the physico-chemical properties, 2D NMR techniques and chemical degradation experiments to be 36-membered macrolides related to azalomycins, scopafungin and guanidylfungins. Shurimycins were active against fungi and Gram-positive bacteria.
MeSH terms
-
Anti-Bacterial Agents / biosynthesis
-
Anti-Bacterial Agents / chemistry*
-
Anti-Bacterial Agents / pharmacology
-
Fermentation
-
Fungi / drug effects
-
Gram-Positive Bacteria / drug effects
-
Hydrolysis
-
Macrolides*
-
Magnetic Resonance Spectroscopy
-
Molecular Conformation
-
Molecular Structure
-
Oxidation-Reduction
-
Spectrometry, Mass, Fast Atom Bombardment
-
Spectrophotometry, Infrared
-
Spectrophotometry, Ultraviolet
-
Streptomyces / metabolism*
Substances
-
Anti-Bacterial Agents
-
Macrolides
-
shurimycin B
-
shurimycin A