Buccal hairy leukoplakia is associated with Epstein-Barr and HIV virus infections. The main symptom is the characteristic hairy lesion on side parts of the tongue without any other clinical signs. Histologically, there are hyperkeratosis, vacuolar degeneration, and presence of Candida, but no inflammatory infiltration. Antiviral drugs led to the regression of lesions, but there is a trend to relapse when treatment is interrupted.